Study of Riamilovir Activity Against SARS-CoV-2 Infection In Syrian Hamsters

The activity of the antimetabolic drug Riamilovir (Triazavirin ® ) was studied on a model SARS-CoV-2 infection Syrian hamsters. Infectious process caused by intranasal administration virus accumulated in Vero-B culture with concentration 4.25×10 4 TCID 50 , volume 26 µl/hamster. effects at dose 20 mg/kg intraperitoneally daily midst infectious were traced to accelerate clearance lungs, prevent body weight loss and severity pulmonary edema, as well preserve mass spleen. protective structure lungs brain are shown, it is suggested that has ability penetrate blood-brain barrier. It concluded antiviral against SARS-CoV-2.